The SD70ACe is similar to the SD70MAC; however, it has been updated to meet the latest EPA regulations for locomotives. Several other changes were included. The radiator on the locomotive is nearly as wide as the cab, and looks similar to the radiator on the SD80 and SD90 series of locomotives. The nose has been modified, producing a much more angular design than previous. The cables and brake lines have been routed beneath the walkways, allowing for easy access by maintenance workers. The SD70ACe is rated at 4,300 horsepower (3,200 kW).

As of 2005, 191 of this locomotive have been produced. Purchasers include BNSF Railway, CSX Transportation, Ferromex, Kansas City Southern Railway, Montana RailLink, CVG Ferrominera Orinoco , Union Pacific Railroad and Quebec North Shore and Labrador Railway, BHP Billiton.